中国科学院药物研究所谭敏佳等多个研究团队合作揭示了人类肺腺癌的蛋白质组学特征。该研究于2020年7月9日发表于《细胞》。因此，这就是选择分子流行病学的原因，不可否认其带来的积极影响。
研究人员对103例中国患者的肺腺癌（luad）进行了全面的蛋白质组学分析。蛋白质组、磷酸化蛋白质组、转录组和全外显子组测序数据的综合分析显示了癌症相关的特征，例如肿瘤相关的蛋白质变体、独特的蛋白质组学特征以及早期或egfr和tp53突变患者的临床结局。基于蛋白质组的luad分层显示了与不同的临床和分子特征相关的三种亚型（s-i、s-ii和s-iii）。
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此外，研究人员鉴定了潜在的药物靶标并验证了hsp90β的血浆蛋白水平是独立队列中luad的潜在预后生物标志物。这些综合蛋白质组学分析可以更全面地了解luad的分子结构，并为更精确的诊断和治疗提供机会。
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据悉，luad的基因组研究提高了人类对该疾病生物学和靶向治疗的理解。但是，luad的蛋白质组学特性仍然知之甚少。
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附：英文原文
title: integrative proteomic characterization of human lung adenocarcinoma
author: jun-yu xu, chunchao zhang, xiang wang, linhui zhai, yiming ma, yousheng mao, kun qian, changqing sun, zhiwei liu, shangwen jiang, minghui wang, lin feng, lei zhao, ping liu, bo wang, xin zhao, hui xie, xiaoyun yang, liyuan zhao, yafei chang, jingya jia, xijun wang, yimin zhang, yaru wang, yikun yang, zhixiang wu, longhai yang, bin liu, teng zhao, shengguo ren, aihua sun, yang zhao, wantao ying, fei wang, guangshun wang, yi zhang, shujun cheng, jun qin, xiaohong qian, yi wang, jing li, fuchu he, ting xiao, minjia tan
issuevolume: 20200709
abstract: genomic studies of lung adenocarcinoma (luad) have advanced our understanding of the disease’s biology and accelerated targeted therapy however, the proteomic characteristics of luad remain poorly understood we carried out a comprehensive proteomics analysis of 103 cases of luad in chinese patients integrative analysis of proteome, phosphoproteome, transcriptome, and whole-exome sequencing data revealed cancer-associated characteristics, such as tumor-associated protein variants, distinct proteomics features, and clinical outcomes in patients at an early stage or with egfr and tp53 mutations proteome-based stratification of luad revealed three subtypes (s-i, s-ii, and s-iii) related to different clinical and molecular features further, we nominated potential drug targets and validated the plasma protein level of hsp 90β as a potential prognostic biomarker for luad in an independent cohort our integrative proteomics analysis enables a more comprehensive understanding of the molecular landscape of luad and offers an opportunity for more precise diagnosis and treatment
doi: 101016jcell202005043